Structural and Biochemical Characterization of the Therapeutic Anabaena variabilis Phenylalanine Ammonia Lyase
نویسندگان
چکیده
منابع مشابه
Optimized condition for enhanced soluble-expression of recombinant mutant anabaena variabilis phenylalanine ammonia lyase.
PURPOSE Recently discovered Anabaena variabilis phenylalanine ammonia lyase (AvPAL) proved to be a good candidate for enzyme replacement therapy of phenylketonuria. Outstanding stability properties of a mutant version of this enzyme, produced already in our laboratory, have led us to the idea of culture conditions optimization for soluble expression of this therapeutically valuable enzyme in E....
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ژورنال
عنوان ژورنال: Journal of Molecular Biology
سال: 2008
ISSN: 0022-2836
DOI: 10.1016/j.jmb.2008.05.025